Current Studies

Precision Medicine Program

PRISM: A multicentre prospective study of the feasibility and clinical value of a diagnostic service for identifying therapeutic targets and recommending personalised treatment for children and adolescents with high-risk cancer.

Tissue Banking

HoTRODS: High Through-put Robotic Screen of Diffuse Pontine Glioma Study

Early Phase

BIOMEDE: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication

ECREST: A Phase 1 Study of Intravenous EGFR-ErbituxEDVSMIT (EEDVSMit) in Children with Recurrent / Refractory Solid or CNS Tumours Expressing Epidermal Growth Factor Receptor (EGFR)

INFORM2: Exploratory multinational phase I/II combination study of Nivolumab and Entinostat in children and adolescents with refractory high-risk malignancies

NORTH: A Phase II Study of Panobinostat in Paediatric, Adolescent and Young Adult Patients with Solid Tumours Including Osteosarcoma, Malignant Rhabdoid Tumour/Atypical Teratoid Rhabdoid Tumours and Neuroblastoma.

PABLO: TCR α+β+/CD19+ cell depleted haploidentical donor stem cell transplantation for paediatric patients.

rEECur: An International Randomised Controlled Trial of Chemotherapy for the Treatment of Recurrent and Primary Refractory Ewing Sarcoma.

Phase III

SIOPEN LINES: European Low and Intermediate Risk Neuroblastoma Protocol.

LOGGIC: Phase III, randomised, international multicentre trial for children and adolescents with low-grade glioma.

Registry

ASSET: Acute Lymphoblastic Leukaemia Subtype and Side-Effects from Treatment (ASSET study) – Nationwide analysis of severe treatment-related toxicity in childhood Leukaemia.

SCI: Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI)