Current Studies

Precision Medicine Program

ZERO2: Precision Medicine for Children with High-risk and Non-high-risk Cancer

PRISM: A multicentre prospective study of the feasibility and clinical value of a diagnostic service for identifying therapeutic targets and recommending personalised treatment for children and adolescents with high-risk cancer.

PREDICT: Assessment of the utility of family-based (trio) whole-genome sequencing for cancer predisposition testing in sequential newly diagnosed paediatric and adolescent cancer patients

Tissue Banking

HoTRODS: High Through-put Robotic Screen of Diffuse Pontine Glioma Study

Early Phase

ECREST: A Phase 1 Study of Intravenous EGFR-ErbituxEDVSMIT (EEDVSMit) in Children with Recurrent / Refractory Solid or CNS Tumours Expressing Epidermal Growth Factor Receptor (EGFR)

INFORM2: Exploratory multinational phase I/II combination study of Nivolumab and Entinostat in children and adolescents with refractory high-risk malignancies

OPTIMISE: Optimal Precision TherapIes to CustoMISE Care in Childhood and Adolescent Cancer

PABLO: TCR α+β+/CD19+ cell depleted haploidentical donor stem cell transplantation for paediatric patients.

DART: Phase I/II trial of deflexifol for refractory/recurrent paediatric ependymoma

LEVI'S CATCH: LEVeragIng Chimeric Antigen Receptor-Expressing T Cells for CHildren with Diffuse Midline Glioma

Phase III

SIOPEN LINES: European Low and Intermediate Risk Neuroblastoma Protocol.

LOGGIC: Phase III, randomised, international multicentre trial for children and adolescents with low-grade glioma.

HR-NBL2: High-risk neuroblastoma study 2.0 of SIOP-Europe-Neuroblastoma/SIOPEN


ASSET: Acute Lymphoblastic Leukaemia Subtype and Side-Effects from Treatment (ASSET study) – Nationwide analysis of severe treatment-related toxicity in childhood Leukaemia.

SCI: Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting With Spinal Canal Involvement (SCI)

ALL Registry: Patient Responses to Treatments: An Acute Leukaemia Registry; Minimal Residual Disease testing; Molecular Subtyping and Biobanking for Future Research